Scottish Institute of Reflexology

CUSHINGS DISEASE?

Cushing's disease can be caused by a pituitary tumor that secretes excessive amounts of adrenocorticotropic hormone (known as ACTH). This hormone stimulates the adrenal glands to produce excessive amounts of cortisol. Other tumors or conditions also may lead to excess secretion of cortisol, such as tumors of the adrenal gland and lung. This is called Cushing's syndrome. If left untreated, Cushing's syndrome (as well as Cushing's disease) can seriously affect the quality and length of life.

The adrenal glands are regulated by the pituitary gland to produce cortisol as needed. Higher amounts are needed in the morning and throughout the early day, with less needed in the evening. This 24-hour rhythm is called a circadian rhythm. Extra cortisol is naturally produced during an illness or any type of physical or psychological stress. Cortisol belongs to a class of hormones called glucocorticoids, which affect almost every organ and tissue. Cortisol helps regulate blood pressure, the immune system, blood sugar, and the metabolism of proteins, carbohydrates, and fats.

Symptoms of Cushing's Disease
These may vary from person to person. Many of the symptoms listed below can be attributed to numerous other diseases if viewed separately. However, several of these symptoms seen together could suggest Cushing's disease.

Moon Face – The face becomes round and may look flushed.

High Blood Pressure- Almost all patients with Cushing's have high blood pressure because of complex actions of cortisol on the kidneys and the blood vessels.

High Cholesterol - High cholesterol levels combined with high blood pressure increase the risk of atherosclerosis.

High Blood Sugar - Diabetes is common in patients with Cushing's. As many as 3% of uncontrolled diabetics may actually have Cushing's. The disorder is due to the effects of cortisol on insulin metabolism of glucose.
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